The APACPH Conference 2025 is dedicated to bringing together public health professionals, researchers, educators, and policymakers to engage in critical discussions on both emerging and persistent challenges confronting global health in an era of disruption. As societies worldwide contend with rapid technological advancements, escalating environmental crises, geopolitical instability, recurring pandemics, and widening health inequities, the conference serves as an essential platform for exchanging evidence-based knowledge, innovative strategies, and collaborative models aimed at strengthening health systems and enhancing resilience across the Asia-Pacific region and beyond. Through the promotion of interdisciplinary dialogue and regional cooperation, the conference seeks to generate actionable insights, encourage forward-thinking approaches, and cultivate sustainable partnerships that advance public health leadership. Ultimately, APACPH 2025 aspires to equip participants with the vision, strategies, and networks required to ensure health systems remain responsive, equitable, and sustainable in the face of ongoing uncertainty and transformation.